This article describes the work of faculty members and administrators at California State University, Fresno to create courses in the General Education (GE) program taught around the Global Challenges framework developed by members of AASCU’s Global Engagement Initiative. The first course, H102, was developed in 2008 for the upper division GE program and was designed specifically and exclusively for the Smittcamp Family Honors College. Two new courses were developed in 2013, one that fulfills a lower division GE requirement in critical thinking, and an upper division GE course that fulfills the Multicultural/International requirement. The authors (developers and instructors of the courses) describe experiences teaching the courses, including how resources are selected, strong and weak assignments, pre- and post-semester survey results, developing the course as part of the GE program, and the unique experience of teaching an interdisciplinary course with the ultimate goal of creating more globally engaged students.